The effect of Ro 11-1781, a calciumantagonist, on atrioventricular conduction
Gmeiner, R.; Simma, H.; Ng, C.K.; Dienstl, F.; Knapp, E.
Zeitschrift für Kardiologie 66(5): 238-241
1977
ISSN/ISBN: 0300-5860 PMID: 878551 Document Number: 120971
The effect of an intravenous bolus of 1 mg/kg Ro 11-1781, a new calciumantagonist, on sinus node automaticity and intracardiac conduction was studied by His-bundle electrography and atrial stimulation. During sinus rhythm, no significant action of Ro 11-1781 on rate, P-A-interval, A-H interval, and H-V-interval was observed. The sinus node recovery time remained unaltered. On atrial stimulation, the St-H-interval was significantly (p less than 0.001) prolonged after Ro 11-1781. Wenckebach Periods occurred at lower stimulation rates in all patients after Ro 11-1781. It is concluded that Ro 11-1781 prolongs av nodal conduction and may be of therapeutic value in the treatment of supraventricular arrhythmias.