Distribution and fate of alpha-naphthl-isothiocyanate (ANIT) in the organs and body fluids of the rat
Breschi, M.C.; Ducci, M.; Tacca, M.; Mazzanti, L.; Giusiani, M.; Poggi, G.; Palagi, U.
Arzneimittel-Forschung 27(1): 122-126
1977
ISSN/ISBN: 0004-4172 PMID: 576810 Document Number: 120743
alpha-Naphthyl-isothiocyanate (ANIT) is a well known toxic substance which induces characteristic hepatic lesions. Its distribution in some organs and body fluids was investigated by using spectrophotometry, gas-chromatography and thin-layer chromatography. The results indicate that ANIT concentrates in the liver, kidneys and blood but not in the brain, urine and bile. Another five ANIT-like substances have also been examined, but no trace of them has been found in these organs and body fluids. The authors suppose that ANIT is metabolized to an unknown metabolite which is responsible for the toxic action of ANIT. None of the ANIT-like substances examined by us can be indentified with this metabolite.