Principles for optimizing and guaging several processes in the technology of vaccine production. I. Several problems in guaging and optimizing thermal sterilization of fluids
Matveev, V.E.; Tarasenko, V.M.; Vorob'ev, A.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 10: 33-37
1977
ISSN/ISBN: 0372-9311 PMID: 919920 Document Number: 120472
Thermal sterilization of fluids--one of the widespread operations in microbiological laboratories and in vaccine production--solves two tasks: provides sterility and maximal preservation of biological value of the sterilized fluid. A possibility and expediency of using some indices for the quantitative assessment of the efficacy of the sterilization regimens, including measurement of the sterilization processes is considered in this work. A possible way of the regimen optimization on the basis of known values of the activation energies of the processes of decomposition of thermolabile components and inactivation of foreign microbial flora is assessed.