Serum estradiol and gonadotropins level in postmenopausal women with or without hormone replacement
Limpaphayom, K.; Taechakraichana, N.; Kittinunvorakoon, C.
Journal of the Medical Association of Thailand 80(3): 147-152
1997
ISSN/ISBN: 0125-2208 PMID: 9175381 Document Number: 1203
Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E-2) was measured in 49 menopausal women, to assess the changing serum level in women with or without hormone replacement. Women in the study group (N=25) received estrogen with or without progestin. The control group (N=24) did not receive any hormone regimen. Serum hormone measurement was done at 0, 6 and 12 month, using time-resolved fluoroimmunoassay method. The results revealed no significant change of FSH, LH and E-2 at 0, 6 and 12 month in the control group. (FSH at 0, 6, 12 month : 55.14+-22.82, 63.90+-24.54, 72.81+-29.58 IU/L, P=0.09; LH at 48.54, 37.29+-39.93, 25.63+-23.58 pmol/L, P=0.17). However, in the study group, FSH and LH significantly decreased but E-2 significantly increased at 6 and 12 months. (FSH at 0, 6, 12 month : 59.33+-22.30, 27.23+-16.31, 29.74+-19.45 IU/L, P lt 0.05; LH at 0, 6, 12 months : 41.4+-17.02, 19.62+-13.66, 15.65+-8.77 IU/L, P lt 0.05; E-2 at 0, 6, 12 months : 47.33+41.25, 280.94+- 174.11, 270.70+-198.65 pmol/L, P lt 0.05). In conclusion, hormone replacement decreased serum gonadotrophin, though not reaching the premenopausal level. However, serum E-2 value was significantly increased close to the level in the follicular phase of normal menstrual cycle.
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