Hydroxyproline in the diagnosis of bone metastases in breast cancer
Gasser, A.B.; Depierre, D.; Alberto, P.; Courvoisier, B.
Schweizerische Medizinische Wochenschrift 107(28): 984-986
1977
ISSN/ISBN: 0036-7672 PMID: 897640 Document Number: 120258
15 patients with breast cancer and proven bone metastases have been studied. Free serum and total urinary hydroxyproline were measured and the ratio (hydroxyproline/creatinine) - 100 in a morning urine specimen was calculated. The preliminary results show elevated free serum hydroxyproline in 8 of 15 patients; total urinary hydroxyproline in a 24-h collection and the ratio hydroxyproline/creatine in a morning urine specimen were elevated in all cases. These results agree with those of the literature. Further studies of free hydroxyproline and of the ratio hydroxyproline/ creatinine in a morning urine specimen in similar patients with provide more information on the possibility of using these measurements, alone or in combination, for the early detection or follow-up under therapy of bone metastases.