Developmental toxicity of naproxen
Burdan, F.; Sykut, J.; Przybylski, P.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 23(134): 155-158
2007
ISSN/ISBN: 1426-9686 PMID: 18044350 Document Number: 12017
Naproxen is a nonsteroidal antiinflammatory drug (NSAID) with an antiinflammatory, analgesic, antipyretic and tocolytic activity. Due to high therapeutical potency and good adult toxicological profile it is available as over-the-counter (OTC) drug. Experimental studies indicated that naproxen inhibited ovulation and readily passed the placental barrier. However, its developmental toxicity is not fully defined. Similar to other NSAIDs, naproxen causes constriction of the ductus arteriosus and fetal anuria or oliguria that could let to pulmonary arterial hypertension and oligohydramnion, respectively. It may also induce lip and/or palate clefts and cardiac malformations, especially the ventricular septal defect.
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