Determination of Reference Values for the Soluble Transferrin Receptor (sTfR) on a Cross Sectional Population Sample

Alexa von Schmiesing; Schmidt, S.A.; Kratzer, W.; Mason, R.A.; Imhof, A.; Steinbach, G.; Akinli, A.S.; Haenle, M.M.; EMIL-Study-Group

Clinical Laboratory 55(5-6): 193-199

2009


ISSN/ISBN: 1433-6510
PMID: 19728552
Document Number: 11984
Background: Aim of the study was to determine reference values for the soluble Transferrin Receptor (sTfR) in a cross sectional population sample. Methods: For the determination of reference values, using a standard calibrated fluorescence-immunoassay, the samples (990 females; 1060 males; 13 - 65 years old) were divided into five groups according to age and sex. Soluble transferrin receptor and ferritin were measured by a fluorescence-immunoassay with AIA-21 (TOSOH BIOSCIENCE, Tessenderlo, Belgium). The sTfR/logFer-Index was calculated by dividing the sTfR by the logarithm of ferritin, the logsTfR/Fer-Index by dividing the logarithm of sTfR by ferritin. Results: Mean sTfR concentration was 1.75 ± 0.39 mg/l in group I (13-17 years), 1.65 ± 0.34 mg/l in group II (18-30 years), 1.60 ± 0.39 mg/l in group III (31-40 years), 1.54 ± 0.39 mg/l in group IV (41-50 years), and 1.59 ± 0.34 mg/l in group V (51-65 years), respectively. A gender-specific difference between the groups was observed: sTfR concentrations were lower in group I (p Conclusions: This is the first cross sectional population based study to determine reference values for sTfR-concentrations. Our results demonstrated age- and gender-specific differences.

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Determination of Reference Values for the Soluble Transferrin Receptor (sTfR) on a Cross Sectional Population Sample