Determination of C1q in vivo increases the sensitivity of direct immunofluorescence test in diagnosing bullous pemphigoid
Bialynicki-Birula, R.K.; Kobuszewska, A.; Kolodziej, T.
Acta Dermatovenerologica Croatica Adc 19(4): 271-273
2011
ISSN/ISBN: 1847-6538 PMID: 22185929 Document Number: 11977
DIF(IgG and/or C3) were positive in 90.2% BP patients. This level of sensitivity of DIF(IgG and/or C3) has been reported by other authors (1-3). Thanks to additional assessment of C1q, the new established DIF(IgG and/or C3 and/or C1q) had a significantly higher sensitivity. DIF (IgG and/or C3 and/or C1q) were positive in all patients (100%). Deposits of IgA and/or IgM were always found in the presence of other deposits (IgG and/or C1q and/or C3); therefore, determination of IgA and/or IgM did not improve the test sensitivity. Based on our experience, we suggest that C1q deposits be determined in BP patients.
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