Dendritic cells and T cells in immunotherapy
O'Neill, D.W.
Journal of Drugs in Dermatology Jdd 9(11): 1383-1392
2010
ISSN/ISBN: 1545-9616 PMID: 21061761 Document Number: 11940
Autologous cellular immunotherapies have been used experimentally in humans to treat many types of cancer. These therapies are divided into two principal types: active cellular immunotherapies that rely on autologous dendritic cells or other antigen presenting cells; and adoptive T-cell therapies, in which large numbers of antigen-specific T lymphocytes are propagated ex vivo and then infused back into the patient. With the FDA approval of the antigen presenting cell vaccine sipuleucel-T for prostate cancer, active immunization has become an accepted approach for the treatment of established cancer.
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