Report of large kinship with familial translocation between chromosomes 21 and 22
Brissenden, J.E.; Costa, M.T.; Roberts, M.H.
Canadian Medical Association Journal 117(12): 1411-1413
1977
ISSN/ISBN: 0008-4409 PMID: 145313 Document Number: 119032
This paper reports a large kinship with a familial (21;22) translocation occurring in both the balanced and the unbalanced states. Recurrence risks for the (21;22) translocation in the unbalanced state are high (14%) for the offspring of female carriers as compared with those for the offspring of male carriers (4%), but the offspring of male carriers appear to have a much higher risk (50%) of being balanced carriers than those of female carriers (30%).