Modification during treatment of the rate of acetylation of isoniazide clinically or biologically detectable hepatic damage
Albengres, E.; Houin, G.; Breau, J.L.; Hirsch, A.; Saltiel, J.C.; Tillement, J.P.; Chrétien, J.
La Nouvelle Presse Medicale 6(32): 2869-2871
1977
ISSN/ISBN: 0301-1518 PMID: 917803 Document Number: 117995
The rate of acetylation of isoniazid is usually constant in a given subject. The authors report here a case where despite an adjusted initial dose there was a decrease in the rate of acetylation during treatment with INH-rifampicin and ethambutol, without hepatic involvement but accompanied by retrobulbar optic neuritis. The role of ethambutol and/or an overdose of isoniazid are discussed. The technique for its estimation is also described.