High incidence of ependymomas induced by BK virus, a human papovavirus: brief communication
Corallini, A.; Barbanti-Brodano, G.; Bortoloni, W.; Nenci, I.; Cassai, E.; Tampieri, M.; Portolani, M.; Borgatti, M.
Journal of the National Cancer Institute 59(5): 1561-1564
1977
ISSN/ISBN: 0027-8874 PMID: 198571 Document Number: 117630
Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified BK virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-fixation tests. A proportion of tumor-bearing animals had antibodies to BKV T-antigen in their sera. BKV could be rescued from 2 tumor cell lines by Sendal virus-mediated fusion with Vero cells. A low, or lack of, oncogenic activity was displayed by BKV inoculated s.c., i.p., or i.v.