Comparison of surgical wound infection after preoperative skin preparation with 4% chlorhexidine [correction of chlohexidine] and povidone iodine: a prospective randomized trial
Paocharoen, V.; Mingmalairak, C.; Apisarnthanarak, A.
Journal of the Medical Association of Thailand 92(7): 898-902
2009
ISSN/ISBN: 0125-2208 PMID: 19626807 Document Number: 11711
Antiseptic scrub and paint can reduce bacterial colonization and postoperative wound infection. Two forms of antiseptics, povidone iodine and chlorhexidine, are commonly used in the operating theater. To study the efficacy of the reduction of bacterial colonization and surgical wound infection among these antiseptic. Five hundred surgical patients were randomly divided into two groups. Povidone Iodine and Chlorhexidine were used for skin preparation in group 1 and 2 respectively Bacterial colonization and postoperative wound infection were examined after skin preparation. Demographic data was analyzed by student's t test; the culture result and surgical wound infection were analyzed by Mantel-Haenszel method for relative risk and 95% CI. There was a significant reduction of bacterial colonization and wound infection after skin preparation in group 2 compared with group 1. Colonization of bacterial and postoperative surgical wound infection were significantly reduced in the chlorhexidine group. Chlorhexidine antiseptic should be the first consideration for preoperative skin preparation.
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