Influencing of the kininogen-Kinin-System by means of a kallikrein-inhibitor during extracorporeal circulation in open heart surgery
Deklerk, J.; Benzer, H.; Haider, W.; Pauser, G.; Stellwag, F.
Der Anaesthesist 26(12): 639-643
1977
ISSN/ISBN: 0003-2417 PMID: 304691 Document Number: 116145
During extracorporeal circulation for open heart surgery an activation of the kininogen-kininsystem occurs with a decrease in plasma-kininogen-levels significantly exceeding the effect of haemodilution, and thus being due to an increased liberation of kinin. This effect could be suppressed by kallikrein inhibition by means of a protease-inhibitor.
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