Amyloidosis in rhesus monkeys with rheumatoid arthritis and enterocolitis
Chapman, W.L.; Crowell, W.A.
Journal of the American Veterinary Medical Association 171(9): 855-858
1977
ISSN/ISBN: 0003-1488 PMID: 411771 Document Number: 115638
Generalized amyloidosis was diagnosed by light and electron microscopy in 4 of 5 monkeys (Macaca mulatta) that had a history of chronic arthritis or chronic intermittent diarrhea, or both. Clinical signs and lesions of arthritis in the monkeys were compatible with diagnostic criteria for rheumatoid arthritis. Shigella sp was cultured from 1 monkey, and 2 other monkeys had colonic lesions characteristic of shigellosis. At necropsy, gross changes attributed to amyloid were seen only in the liver. Amyloid deposits in the liver, spleen, mesenteric lymph nodes, kidney, heart, adrenal glands, and other organs were determined by staining reactions and fine structural characteristics.