Microvascular anastomosis using a blood product sealant-adhesive
Pearl, R.M.; Wustrack, K.O.; Harbury, C.; Rubenstein, E.; Kaplan, E.N.
Surgery Gynecology and Obstetrics 144(2): 227-231
1977
ISSN/ISBN: 0039-6087 PMID: 319545 Document Number: 115022
In this experimental model, we have shown that a four suture repair with a biologic sealant adhesive significantly reduces hemorrhage and reduces operative time, while allowing a flap survival comparable to that obtained with standard techniques in rats undergoing a microvascular anastomosis. In heparinized rats undergoing the same procedure, the sealant adhesive significantly decreases hemorrhage and increases flap survival. Of significance is the fact that the platelet-fibrinogen-thrombin adhesive is biodegradable and does not induce a tissue reaction. We believe that this physiologic adhesive may become a useful adjunct in digital reimplantation. It appears to reduce operative time and heparin-induced bleeding.