Results of five different types of chemotherapy in 252 cases of typhoid fever
De Ritis, F.; Giammanco, G.; Manzillo, G.; Schisa, C.; Mancini, A.; Florentino, F.; Guerriero, M.
Materia Medica Polona. Polish Journal of Medicine and Pharmacy 9(4): 322-327
1977
ISSN/ISBN: 0025-5246 PMID: 599964 Document Number: 114096
Patients (252) with typhoid fever were treated with 5 different drug regimens, including chloramphenicol alone, chloramphenicol + ampicillin, tri-comexazole, tri-comexazole + ampicillin and chloramphenicol + tri-comexazole. The combination of chloramphenicol and tri-comexazole resulted in a shorter duration of the febrile period as compared to other regimens; the combination of chloramphenicol + ampicillin resulted in complete recovery of all patients, with none of them becoming a carrier. Although chloramphenicol remains an effective drug in treatment of typhoid fever, one can resort to alternative treatments which might prevent emergence of strains resistant to chloramphenicol.