Elevated systolic pressure following chronic low-level cadmiun feeding
Perry, H.M.; Erlanger, M.; Perry, E.F.
American Journal of Physiology 232(2): H114-H121
1977
ISSN/ISBN: 0002-9513 PMID: 842643 Document Number: 113761
Groups of 16 female Long-Evans rats received 0, 1, 2.5, 5, 10, 25, and 50 mg Cd/l drinking water (ppm), from the time they were weaned until they were 30 mo. old. Systolic pressure was measured indirectly in triplicate at 6-mo. intervals. Both 2.5 and 5 ppm Cd consistently induced significant elevations in mean systolic pressure, ranging from 13-33 mmHg. At 6 mo., 10 and 25 ppm Cd also induced significant elevations, whereas at 12 mo. and subsequently 1 ppm Cd induced significant elevations. With 10 ppm Cd or less weight gain was normal and there was no evidence of Cd toxicity. With 25 and 50 ppm Cd weight gain was diminished, suggesting toxicity. Five rats with each level of exposure were sacrificed every 6 mo. from a 2nd population of similarly handled rats in order to determine renal Cd concentrations. Cd intakes that had induced hypertension were associated with mean renal Cd concentrations ranging from 5-50 .mu.g/g kidney.