Enkephalins inhibit intestinal motility: mode of action
Mitznegg, P.; Domschke, W.; Sprügel, W.; Domschke, S.; Subramanian, N.; Wünsch, E.; Moroder, L.; Demling, L.
Acta Hepato-Gastroenterologica 24(2): 119-120
1977
ISSN/ISBN: 0300-970X PMID: 857559 Document Number: 113538
In the guinea pig isolated terminal ileum the opioid pentapeptides, methionine-enkephalin and leucine-enkephalin, dose-dependently inhibit contractile responses induced by electrical field stimulation releasing endogenous acetylcholine, and by specific noncholinergic compounds including histamine, barium chloride, and beta-acetyl-digoxin. Tissue levels of cAMP and cGMP remain unchanged. We conclude that enkephalins exert their effects by a direct action at or within the muscle cell and may play a physiological role in the local control of the gut smooth muscle motility.