A case of myxoedema coma successfully treated by low dose oral triiodothyronine
Graham, J.J.; Harding, P.E.
Australian and New Zealand Journal of Medicine 7(2): 163-168
1977
ISSN/ISBN: 0004-8291 PMID: 268174 Document Number: 113521
Myxedema coma is rare and is probably rarer in a warm climate such as Australia. It carries a high mortality rate and its correct management is still a controversial issue. A case of severe myxedema coma who was successfully treated is described. Thyroid hormone was replaced in the form of triiodothyronine and cholesterol with a rapid rise of plasma T3 into the euthyroid range. There was a defect in water excretion which was rapidly reversed as renal function returned to normal. Review of the literature suggests that low dose oral therapy with T3 is a satisfactory form of initial management.