Cytogenetic and immunoglobulin markers of human leukemic B-cell lines
Minowada, J.; Oshimura, M.; Tsubota, T.; Higby, D.J.; Sandberg, A.A.
Cancer Research 37(9): 3096-3099
1977
ISSN/ISBN: 0008-5472 PMID: 406986 Document Number: 113345
This study describes the establishment of two permanent leukemic B-cell lines (BALM-1 and -2) originating from the blood cells of a patient with a B-cell type of acute lymphoblastic leukemia. The cells of BALM-1 and -2 exhibited cell surface markers compatible with B-cell origin. The identity between the leukemic cells in vivo and those of the BALM lines was established on the basis of the karyotypic picture, including marker chromosomes 14q+ and t(12;17;?) and cell surface immunoglobulins (K, delta, and mu chain determinants).