Enhancement of human lymphocyte responses to phytomitogens in vitro by incubation at elevated temperatures
Ashman, R.B.; Nahmias, A.J.
Clinical and Experimental Immunology 29(3): 464-467
1977
ISSN/ISBN: 0009-9104 PMID: 589865 Document Number: 113313
Incubation of human lymphocytes with PHA or Con A at 39 degrees C for 3 days caused a consistent, statistically significant, increase in [3H]thymidine uptake, compared with cultures incubated at 37 degrees C. The responses were also significantly increased after 2 days of incubation, suggesting that hyperthermia not only enhanced, but also caused an earlier onset of the mitogen response.
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