Experimental autoimmune thyroiditis in the vervet monkey
Pudifin, D.J.; Duursma, J.; Brain, P.
Clinical and Experimental Immunology 29(2): 256-260
1977
ISSN/ISBN: 0009-9104 PMID: 409579 Document Number: 113182
Autoimmune thyroiditis was induced in two vervet monkeys by immunizing them with human thyroid extract. As expected, both animals developed cytotoxic antibodies which were active against human thyroid and other human cells in tissue culture. In addition, a second serum factor was detected. This was capable of sensitizing human thyroid (and other) cells and rendering them susceptible to killing by normal lymphocytes. This finding implicates antibody-dependent cell-mediated cytotoxicity in the pathogenesis of autoimmune thyroiditis.