Lysis of red blood cells in some haemolytic anaemias--the lytic effect of agkistrodon piscivorus venom in vitro
Brabec, V.; Kornalík, F.
Folia Haematologica 104(3): 428-435
1977
ISSN/ISBN: 0323-4347 PMID: 72030 Document Number: 113169
The lysis of red blood cells induced by A. piscivorus venom (APV) in vitro in the presence and/or in the absence of plasma was examined in autoimmune hemolytic anemia (AIHA), hereditary spherocytosis (HS) and paroxysmal nocturnal hemoglobinuria (PNH). Hemolysis did not differ from that of normals in AIHA, it was slightly increased in HS and significantly higher in PNH, but only in the presence of autologous or normal homologous plasma. The mechanism of PNH blood cell lysis, which is probably related to the activation of the 3rd complement component, is discussed.