Onset of cell proliferation in the shortened gut. Colonic hyperplasia after ileal resection
Nundy, S.; Malamud, D.; Obertop, H.; Sczerban, J.; Malt, R.A.
Gastroenterology 72(2): 263-266
1977
ISSN/ISBN: 0016-5085 PMID: 830575 Document Number: 112719
Cytokinetics in colonic mucosa were studied after ileal resection in young female rats. The RNA content of the transverse colon was increased 32% after 7 days; after 14 days the increase was present throughout the colon. The DNA content of the ascending colon increased 29% after 10 days. Specific activity of DNA labeled with [3H-methyl]thymidine was elevated 29% in the ascending colon and elevated 49% in the descending colon on the 7th postoperative day. Colonic cell proliferation is stimulated within 1 week of ileal resection.