CYFRA 21-1 as a Tool for Distant Metastasis Detection in Lung Cancer
J. L. Cabrera-Alarcon; Carrillo, A.-Vico; Santotoribio, J.D.; Leon, A.-Justel; Sanchez, R.-Gil; Gonzalez, A.-Castro; Guerrero, J.M.
Clinical Laboratory 57(11-12): 1011-1014
2011
ISSN/ISBN: 1433-6510 PMID: 22239035 Document Number: 11267
Background: A study to analyse tumor markers (CEA, CA125, CA15.3, CA19.9, CYFRA 21-1, and NSE) for metastasis detection in lung cancer patients. Methods: Serum tumor markers from 73 lung cancer patients were measured before they were diagnosed. After lung cancer diagnosis, tumor markers were analyzed for the detection of distant metastases. Results: In NSCLC patients CYFRA 21-1 and NSE showed differences between stage IV and any of the other stages, p <0.05. The accuracy for metastasis detection was AUC = 81.5 % for CYFRA 21-1 and AUC = 78.6 % for NSE. CYFRA 21-1 (OR = 1.406; 95 % CI, 1.087 - 1.821, p <0.01) and NSE (OR = 1.197; 95 % CI, 1.011 - 1.416, p <0.05) were independent predictors for metastasis presence. No tumor marker showed significant differences ac-cording to stages in SCLC patients. Conclusions: CYFRA 21-1 could be used as a screening tool for metastasis detection in lung cancer patients without symptoms of metastasis as well as CYFRA 21-1 and NSE in NSCLC patients.
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