The value of acetylsalicylic acid for the prevention of postoperative thromboembolic complications
Pfenninger, M.; Gruber, U.F.
Schweizerische Medizinische Wochenschrift 107(38): 1335-1338
1977
ISSN/ISBN: 0036-7672 PMID: 918588 Document Number: 111134
All studies on the value of acetylsalicylic acid for the prevention of postoperative thromboembolic complications have been evaluated. Controlled, prospective and randomized studies have been analyzed only where the incidence of postoperative deep vein thrombosis or pulmonary emboli was proven by objective diagnostic methods such as the fibrinogen test, phlebography or autopsy. In 6 studies there is no significant reduction in the incidence of deep vein thrombosis in general surgical and orthopedic patients after acetylsalicylic acid prevention. One study, though it has definite methodological defects, does suggest a significant reduction in the number of postoperative fatal pulmonary emboli in 120 patients with fractures of the upper end of the femur. On the basis of all these data, the prevention of postoperative thromboembolic complications by means of acetylsalicylic acid cannot be recommended.