Hypokalemic, metabolic alkalosis induced by high-dose ampicillin sodium
Gill, M.A.; DuBé, J.E.; Young, W.W.
American Journal of Hospital Pharmacy 34(5): 528-531
1977
ISSN/ISBN: 0002-9289 PMID: 326044 Document Number: 110672
A case of hypokalemic metabolic alkalosis precipitated by high-dose intravenous ampicillin sodium is discussed. Cases of hypokalemic metabolic alkalosis attributable to ampicillin sodium have not been reported previously. There have been reports of this phenomenon associated with high doses of penicillin sodium and carbenicillin disodium. The possible mechanism of antibiotic-induced hypokalemic metabolic alkalosis is discussed. It is suggested that most cases of antibiotic-induced hypokalemia respond to oral or intravenous potassium chloride.