Possible disorder of tissue immunity function in mothers who have given birth to a child with Down's disease
Davidenkova, E.F.; Sokolova, S.M.; Butomo, I.V.; Khitrikova, L.E.; Chukhlovin, A.B.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 77(6): 863-865
1977
ISSN/ISBN: 0044-4588 PMID: 143174 Document Number: 110267
The rates of DNA synthesis were studied in PHA-stimulated lymphocytes from the peripheral blood of mothers giving birth to a child with Down's disease. For control purposes a group of donors of the same age and sex were studied as wells. A decrease of 3H-thymidine incorporation was detected in the lymphocytes of the mothers of such children. The found differences were due to a drop of lymphocyte PH-reactivity in the older maternal age group (over 30 years). Interrelation between the changed function of the maternal immune system and the birth of children with chromosome unbalance are discussed.