Antioxidant Defense in Patients with Chronic Viral Hepatitis B and C Type
Namiduru, E.S.; Namiduru, M.; Tarak, M.çioğlu; Armağan Toy
Clinical Laboratory 56(5-6): 207-213
2010
ISSN/ISBN: 1433-6510 PMID: 20575468 Document Number: 11008
Background: The aim of the present study was to determine erythrocyte glutathione, superoxide dismutase, catalase, glutathione peroxidase, and serum total antioxidant response levels in a large chronic viral hepatitis group who had no antiviral treatment, and also the relationship of these parameters with viral load, fibrosis score, and necro-inflammation of the liver. Methods: 200 patients who were diagnosed with chronic viral hepatitis and 107 healthy subjects were included in this study. Antioxidant parameters were measured spectrophotometrically. The viral load was assayed using a polymerase chain reaction technique. Histopathologic findings in the liver were scored as necro-inflammatory activity and fibrosis according to Ishak-Knodell score. Results: Erythrocyte superoxide dismutase, catalase, glutathione peroxidase activities, glutathione, and serum total antioxidant response levels were significantly lower in patients than in controls (p Conclusions: Our data suggest the insufficiency of an antioxidant barrier in patients with chronic viral hepatitis, but the decrease in antioxidant systems was not correlated with viral load, necro-inflammatory activity, and fibrosis score in the liver.
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