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Long-retained metabolites of delta9- and delta8-tetrahydrocannabinols identified as novel fatty acid conjugates

Leighty, E.G.; Fentiman, A.F.; Foltz, R.L.

Research Communications in Chemical Pathology and Pharmacology 14(1): 13-28

1976

ISSN/ISBN: 0034-5164
PMID: 935647
Document Number: 109425
Long-retained metabolites of delta9-tetrahydrocannabinol (delta9-THC) and delta8-tetrahydrocannabinol (delta8-THC) previously detected in the liver, spleen, fat, and bone marrow of the rat after I.V. or I.P. injections of 14C-delta8-THC or 14C-delta9-THC, have been identified as fatty acid conjugates of 11-hydroxy-delta9-THC and 11-hydroxy-delta8-THC. Characterization of the metabolites was facilitated by their large-scale in vitro production from 11-hydroxy-delta9-THC and 11-hydroxy-delta8-THC with a rat-liver microsomal enzyme system. Conjugation of long-chain fatty acids to drugs or their hydroxylated metabolites may have considerable biological significance.

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