The role of thrombosis in renal allograft rejection
Kazatchkine, M.; Bariety, J.; Caen, J.P.
Pathologie-Biologie 24(7): 497-508
1976
ISSN/ISBN: 0369-8114 PMID: 790276 Document Number: 108857
Platelets and intravascular coagulation are involed in the pathogenesis of renal allotransplant rejection phenomena: fibrin deposition is a prominent feature of hyperacute rejection; arteriolar microthromboses when they are present, worsen the prognosis of an acute reversible rejection; the organisation of platelets and fibrin deposits on the intima may lead to the "endarteritis obilterans" of chronic bascular rejection. The interactions between endothelium, platelets, coagulation, fibrinolysis and cellular or humoral effectors of the immune respone were studied and special reference was made to their role in vascular rejection. The poor prognosis in vasuclar lesions justifies therapeutic trials with drugs inhibiting the early events of thrombogenesis.