Characteristics of morphological manifestations of the leukemic process developing against a background of regenerating hematopoietic tissue
Svirnovskiĭ, A.I.; Seniushkina, O.D.
Arkhiv Patologii 38(8): 65-71
1976
ISSN/ISBN: 0004-1955 PMID: 985140 Document Number: 108592
Cyto- and histological changes in the spleen, liver, and other organs of mice of 2 lines with leukosis transplanted against the background of regeneration of the hemopoietic tissue were studied. The reparative regeneration of the hemopoietic organs was caused by preliminary administered hydrocortison. The regeneration of the hemopoietic tissue temporary inhibited proliferation of leukemic cells. Moreover, less pronounced leukemic infiltration was noted in the organs, their size increased more slowly and retained longer the histological structure. Better results were obtained on the experimental model of leukosis with a moderate rate of growth and at early stages of regeneration. Basing on the analysis of the morphological substrate, interaction between regeneration of the hemopoietic tissue and leukemic growth the authors draw a conclusion about the activation in the regenerating tissue of mechanisms of natural anti-tumour protection.