Cross-resistance of transformed mouse cells to some drugs
Stovrovskaya, A.A.; Stromskaya, T.P.; Serpinskaya, A.S.; Kaszás, I.; Schuler, D.; Pogosianz
Acta Biologica Academiae Scientiarum Hungaricae 27(1): 37-44
1976
ISSN/ISBN: 0001-5288 PMID: 186990 Document Number: 108489
The Colcemid-resistant L--53 cell strain was examined for cross-resistance to metaphase inhibotors (Vincristine, Vinblastine, estradiol-17beta), an antitumor antibiotic (Rubomycin C) and an alkylating agent (Lycurim), compared with the Colcemid-sensitive L cells. The L-53 cells proved to be resistant besides colchicine to Vincristine, Vinblastine and estradiol-17beta concerning their antimitotic effect. The comparison of the viability of L and L-53 cells in the presence of Rubomycin C and Lycurim showed a resistance of the L-53 cells to Rubomycin C, while the effect of Lycurim was the same on both cell lines. The chromosome-mutagenic action of Lycurim was also equal on both cell lines.