Effect of insulin on the adipose tissue of patients with diabetes mellitus
Iaroshevskiĭ, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 82(11): 1322-1324
1976
ISSN/ISBN: 0365-9615 PMID: 1016709 Document Number: 108187
A study was made of insulin sensitivity of the adipose tissue biopsied in 11 healthy women, and in 10 women with normal weight suffering from newly-detected diabetes mellitus. In difference from healthy persons in the adipose tissue of patients suffering from diabetes, insulin in a concentration of 50 mu/ml failed to enhance the oxidation of glucose to CO2, and in a concentration of 50 and 100 mu/ml failed to enhance the glycogen synthesis from glucose. Reduction of the sensitivity of different ways of glucose metabolism in the adipose tissue to insulin in patients suffering from diabetes mellitus pointed to the possibility of disturbance of insulin interaction with the cell membrane in this disease.