Objectivization of the protamine sulfate test through photometric measurements
Thiele, G.; Fiedler, H.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 31(14): 542-544
1976
ISSN/ISBN: 0044-2542 PMID: 960879 Document Number: 107660
The demonstration of monomeric complexes of fibrin in the blood is regarded as a secure sign of an increased consumption of coagulation factors in the sense of a consumption coagulopathy. As a simple and sensitive method for the demonstration of these intermediate products of the coagulation the protamine sulphate test proved its worth in clinical practice. The subjective judgment of this test-tube test frequently becomes difficult in the borderline region between normal and pathologic. On the basis of own comparative investigations it could, however, be demonstrated that by means of photometric measurements an objective and exact evidence about the result of the protamine sulphate test can be made. It is referred to the advantages in the judgment of the course of a consumption coagulopathy during the treatment.