Paroxysmal nocturanal hemoglobinuria and marrow failure treated by infusion of marrow from an identical twin
Fefer, A.; Freeman, H.; Storb, R.; Hill, J.; Singer, J.; Edwards, A.; Thomas, E.
Annals of Internal Medicine 84(6): 692-695
1976
ISSN/ISBN: 0003-4819 PMID: 779563 Document Number: 106908
An 18 yr old white Canadian male patient with paroxysmal nocturnal hemoglobinuria and refractory marrow failure received a marrow infusion from his normal identical twin brother without prior ablation of the patient's marrow by drugs or irradiation. After 2 yr of follow-up, the patient was well with no evidence of clinical disease or significant hematological abnormality. Normal marrow stem cells apparently can have a selective advantage over the abnormal paroxysmal nocturnal hemoglobinuria clone.