The epidemiology and virology of C-type virus-associated hematological cancers and related diseases in wild mice
Gardner, M.B.; Henderson, B.E.; Estes, J.D.; Rongey, R.W.; Casagrande, J.; Pike, M.; Huebner, R.J.
Cancer Research 36(2 Part 2): 574-581
1976
ISSN/ISBN: 0008-5472 PMID: 175918 Document Number: 106885
In several different populations of wild mice, observed over a 35-month period in laboratory geriatric colonies, a direct correlation was found between the prevalence and titer of spleen complement-fixing gs (p30) antigen and C-type particles in newly trapped healthy mice and a predilection to lymphoma and a hind leg paralytic disease upon aging. Other studies have established the indigenous C-type virus as the essential etiological determinant of both diseases in wild mice. An increased incidence of breast carcinomas, hepatomas, and pulmonary adenomas associated with C-type virus also occurred in the lymphoma-paralysis-prone colony as compared with the tumor-resistant colonies.