Experimental model of bronchial asthma
Müller, E.; Bergmann, K.C.; Lachmann, B.; Vogel, J.
Zeitschrift für Erkrankungen der Atmungsorgane 144(3): 246-253
1976
ISSN/ISBN: 0303-657X PMID: 960767 Document Number: 106528
Allergic asthma-like attacks were induced in guinea pigs by intraperitoneal injections of Ovalbumin and following inhalation of Ovalbumin aerosol. The animals were narcotized, tracheotomized and a small catheter was placed in mid-oesophagus. The quantities: oesophageal pressure, respiratory flow and tidal volume were measured and recorded on magnetic tape during spontaneous breathing. A technique was applied for automated computation of the parameters of respiratory mechanics using a digital computer. The parameters compliance, resistance, work of breathing and power of breathing showed typical pathological variances and characteristic response-curves in the experimental phases during and after the asthma attacks. These parameters became normal after the injection of Alupent.