Hereditary angioedema: modification of clinical manifestations with androgens
Davis, P.J.; Davis, F.B.; Charache, P.
Birth Defects Original Article Series 12(6): 283-287
1976
ISSN/ISBN: 0547-6844 PMID: 974251 Document Number: 106465
HAE is an autosomal dominant trait of decreased levels or function of circulating and tissue C'1 esterase inhibitor. The clinical illness is characterized by disabling episodes of peripheral, oropharyngeal and gut-wall edema. Long-term fluoxymesterone treatment of 5 affected males (393 patient-months) and oxymetholone treatment of 6 affected females (204 patient-months) has significantly decreased the frequency of attacks of edema without substantive side effects.