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Prolactin in cerebrospinal fluid and dopamine function in man

Jimerson, D.C.; Post, R.M.; Skyler, J.; Bunney, W.E.

Journal of Pharmacy and Pharmacology 28(11): 845-846

1976

ISSN/ISBN: 0022-3573
PMID: 11298
Document Number: 106383
Dopamine-active drugs produce predictable changes in CSF prolactin, and these alterations are in the same direction as the plasma prolactin responses to similar compounds. The decrease in prolactin with piribedil apparently reflects direct dopamine receptor stimulation by the drug, while the concomitant decrease in HVA accumulations may represent a secondary decrease in dopamine synthesis. Increased prolactin in the pimozide-treated patients would be compatible with dopamine receptor blockade, even though the HVA accumulations were not consistently elevated. Prolactin response may provide a relatively direct and sensitive index of pharmacologically-induced alterations in central dopamine receptor activity.

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