Convulsive thresholds and the activity of anticonvulsants in electroseizure test. the role of serotoninergic system
Przegaliński, E.
Polish Journal of Pharmacology and Pharmacy 28(2): 143-155
1976
ISSN/ISBN: 0301-0244 PMID: 934946 Document Number: 105920
The effect of different compounds modifying the activity of serotoninergic system on the convulsive threshold and on anticonvulsant action of phenyltoin (PHEN) phenobarbital (PHB), m-bromophenyl succinimide (BPHSI) and acetazolamide (ACA) in electroseizure test was studied. The obtained results suggest that 5-HT plays a significant role in the convulsive threshold and in ACA anticonvulsant action. No correlation, however, was observed between anticonvulsant action of the studied drugs and their influence on 5-HT level in brain.