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Transfer of the genetic information of oncornaviruses by means of tumor cell DNA

Kniazev, P.G.; Kuznetsov, O.K.; Perevozchikov, A.P.; Korobitsyn, L.P.; Zhudina, A.I.

Voprosy Onkologii 22(1): 47-53

1976

ISSN/ISBN: 0507-3758
PMID: 178103
Document Number: 105561
The infection process was reproduced in the culture of chick embryonal cells by means of: a) DNA isolated from chick Rous sarcoma (Carr-Zilber strain); b) DNA from blood cells of chicks with myeloblastosis (strain A); c) DNA from Rous virus malignified (Prague strain) rat cells (XC). Antigenic properties of the virus, transfected with DNA from chick Rous sarcoma, would differ from the original parental strain (Carr-Zilber RSV), that evidences the possibility of a partial transfer of genetic information in transfection. A suggestion is made on four presumable variants of oncornaviruses transfection by means of tumor cells DNA.

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