Electron microscopic study of the kinetics of smallpox vaccine interaction with alveolar macrophages when administered intratracheally
Osipov, V.I.; Vorob'ev, A.A.; Patrikeev, G.T.; Zemskov, E.M.; Gutorova, V.I.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 17-19
1976
ISSN/ISBN: 0372-9311 PMID: 948955 Document Number: 105504
Electron microscopy was applied to the study of the dynamics of endocytosis of smallpox vaccine by alveolar macrophages in intratracheal immunization of guinea pigs; 5 to 15 minutes after administration of smallpox vaccine the viruses were absorbed on the macrophage surface, penetrated into the cells by invagination and vesiculation. A possibility of adaption of smallpox virus in the alveolar macrophages 12 hours after the vaccination was confirmed documentally.