In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones
Millington, D.S.; Golder, M.P.; Cowley, T.; London, D.; Roberts, H.; Butt, W.R.; Griffiths, K.
Acta Endocrinologica 82(3): 561-571
1976
ISSN/ISBN: 0001-5598 PMID: 180740 Document Number: 104388
The effects of ACTH, prolactin and other protein hormones on the synthesis and secretion of steroid hormones by tissues from a feminizing adrenocortical carcinoma removed from a post-menopausal female were described. Steroid production by the tissue was determined by high resolution-mass fragmentography and by radioimmunoassay. Prolactin and ACTH stimulated the synthesis of estrogens by the tissue whereas GH, LH and ACTH were more effective than prolactin in stimulating androgen synthesis. The effect of protein hormones, other than ACTH, on adenylate cyclase activity of this tumor tissue indicated a lack of specificity of the membrane receptor sites.