The effect of dietary sodium chloride on blood pressure, body fluids, electrolytes, renal function, and serum lipids of normotensive man
Kirkendall, A.M.; Connor, W.E.; Abboud, F.; Rastogi, S.P.; Anderson, T.A.; Fry, M.
Journal of Laboratory and Clinical Medicine 87(3): 411-434
1976
ISSN/ISBN: 0022-2143 PMID: 1249473 Document Number: 104116
Eight normotensive white men 24 to 47 years old were given diets of low, moderate, and high salt content, 10, 210 and 410 m-equiv Na with constant K intakes, each for at least 4 weeks. There was a tendency for bodyweight, serum Na, exchangeable Na and inulin space to increase. Indirect measurements indicated no change in blood pressure, either supine or upright, during the 3 study intervals. Inulin clearance and, presumably, glomerular filtration rate rose with increase in dietary salt. K excretion in urine rose progressively as salt intake increased. Total body K tended to decrease with increase in dietary salt. There was no change in the excretion of Ca, Mg, P, or in blood K or total body water. Serum cholesterol and triglyceride values were not appreciably affected by the Na intakes. Plasma renin activity and aldosterone in urine rose progressively with Na restriction.