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Antibody against the antigen receptor of a plasmacytoma prolongs survival of mice bearing the tumor

Beatty, P.G.; Kim, B.S.; Rowley, D.A.; Coppleson, L.W.

Journal of Immunology 116(5): 1391-1396

1976

ISSN/ISBN: 0022-1767
PMID: 1270800
Document Number: 104073
A transplantable plasmacytoma, TEPC-15 in BALB/c mice, induces a transient antibody response directed against the combining region of the myeloma protein produced by the tumor. Mice immunized with mitomycin-treated tumor cells produce similar antibody but do not develop tumor; mice so immunized survive longer than untreated mice when inoculated with viable TEPC-15 cells. This protection afforded by immunization can be transferred by serum alone; the protective effect of passively given serum is eliminated by absorbing out antibody directed against the myeloma protein.

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