Wells syndrome: an enigmatic and therapeutically challenging disease
Chung, C.L.; Cusack, C.A.
Journal of Drugs in Dermatology Jdd 5(9): 908-911
2006
ISSN/ISBN: 1545-9616 PMID: 17039661 Document Number: 10393
Wells syndrome, also known as eosinophilic cellulitis, is an uncommon condition whose etiology often remains a mystery. Patients present with recurrent cutaneous swellings that are often cellulitic in appearance. Histopathologic evaluation of the skin lesions reveals a dense dermal eosinophilic infiltrate, marked edema, and characteristic "flame figures". Notably, the picture is devoid of vasculitis. Therapy with low-dose systemic steroids has proven variably successful. Clinical evidence lending support for the efficacy of other medications has been, for the most part, anecdotal. We present a case of Wells syndrome, review the literature, and discuss therapeutic options.
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