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Glucose antimetabolites and hunger (theoretical article)

Rezek, M.; Kroeger, E.A.

Journal of Nutrition 106(2): 143-157

1976

ISSN/ISBN: 0022-3166
PMID: 765438
Document Number: 103871
A decrease in the cellular utilization of glucose produced by several glucose antimetabolites and especially by 2 deoxy-D-glucose stimulates food intake. Experiments in which glucose antimetabolites have been given to influence selectively the central and peripheral glucosensitive loci suggest a possible mechanism for the action of the substances. The mechanisms by which glucose antimetabolites and exogenous insulin induce cellular glucoprivation and the subsequent changes in food intake are compared and discussed.

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