Long-term treatment with medroxyprogesterone in 4 children with true precocious puberty
Pasquino, A.M.; Fraioli, F.; Iannetti, P.; Campea, L.; Carratu, A.; Boscherini, B.
Minerva Pediatrica 28(8): 517-525
1976
ISSN/ISBN: 0026-4946 PMID: 824544 Document Number: 103836
The article presents the case of 4 little girls, aged 7-9, affected by true pubertas praecox, with secondary sex characteristics, menstruation, and precocious skeletal growth. One of the girls was also affected by epilepsy, and one by McCune-Albright syndrome. All girls were treated, over a period of 2-5 years, with injections of medroxyprogesterone acetate. Such treatment caused, in all patients, regression of mammary hypertrophy, reduction of plasma gonadotropins, and disappearance of menstruation. Skeletal growth was slowed down, thus improving prognosis for final stature. Such results coincide with others published in the literature on the subject.